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Because the Yorkiepoo is a fairly new crossbreed, the coat varies tremendously. Use hypoallergenic shampoos on affected dogs. Our ratings are generalizations, and they're not a guarantee of how any breed or individual dog will behave. Not all Yorkipoos will get any or all of these diseases, but it's important to be aware of them if you're considering this breed. Some dogs will let a stern reprimand roll off their backs, while others take even a dirty look to heart. Today, most Yorkipoo litters are still the result of first-generation breeding, but some breeders have concentrated on multigenerational crosses in an effort to see the Yorkipoo produce offspring who confirm more consistently to the desired traits.